Scripps research scientists create molecular map to guide treatment of multiple sclerosis

A team of scientists from The Scripps Research Institute, collaborating with members of the drug discovery company Receptos, has created the first high-resolution virtual image of cellular structures called S1P1 receptors, which are critical in controlling the onset and progression of multiple sclerosis and other diseases. This new molecular map is already pointing researchers toward promising new paths for drug discovery and aiding them in better understanding how certain existing drugs work. The molecular structure, described in the February 17, 2012 issue of the journal Science, is unique as the first-ever-to-be-determined lipid G protein-coupled receptor (GPCR). Molecules of this type play important roles in everything from cancer to metabolism, and this recent success should pave the way for researchers to establish the structures of other family members.

"There's something special about the S1P1 receptor," said Hugh Rosen, MD, PhD, a Scripps Research chemical biologist who co-led the work with Raymond Stevens, PhD, a structural biologist also from The Scripps Research Institute. "The biological consequences of even small changes with this receptor are profound. Understanding its structure provides clues about fundamental processes important in both health and disease."

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Musician With MS Will Perform Benefit in Easton

Wilson's Pamela Taylor to play concert at Trinity Episcopal to raise money for multiple sclerosis foundation.

Musician Pamela Taylor has lived with for most of her life, although she didn't know this until her diagnosis a few years ago.

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Walk MS turns ordinary Stamford woman into an "extraordinary machine"

STAMFORD, CT - Sometimes a stranger has an uncanny ability to understand your feelings better than anyone else. For Stamford native Sara Bromley, singer-songwriter Fiona Apple filled those shoes.

When Apple released her third album "Extraordinary Machine" in 2005, she certainly did not have MS in mind. The first track, which features the same name, addresses Apple's struggle to feel like herself again after the end of a long-term relationship. Sara Bromley wasn't going through a breakup at the time, but Fiona Apple's words seemed to resonate with her deeper than any other song she had heard before.

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CNS Neurologist to Present at International Conference on Neurovascular Disease

Dr. Benson's presentation will center on the role blood flow to the brain may impact such diseases as Multiple Sclerosis. The symposium is presented by the International Society for Neurovascular Disease.

Randall Benson, MD, Medical Director of the Novi, MI-based Center for Neurological Studies (CNS), will present research before an international symposium on neurovascular disease on February 22 in Orlando, FL. Dr. Benson's presentation will center on the role blood flow to the brain may impact such diseases as Multiple Sclerosis (MS). The symposium is presented by the International Society for Neurovascular Disease (ISNVD).

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