Multiple Sclerosis Medication
Currently, numerous drug trials for various multiple sclerosis medication are on-going all over the world. So far, there have been a few disappointments just as there are positive results.
Take note that the following multiple sclerosis medication have been already evaluated in numerous clinical trials which measure the below endpoints: relapse rate reduction, delay in the disability' sprogression, presence of T2 lesions, any increase in the atrophy of the brain, T1 holes increase.
It is highly advisable that patients be also warned and educated with regards to these medicines as they are not at all curative. Also, treatment of acute MS attacks must be reserved for symptoms which are functionally disabling.
Other therapeutic practices in treating multiple sclerosis include IVIg or intravenous immunoglobulin, combination therapy, bone marrow transplant and hormonal treatment.
The following are FDA-approved drugs for use on specific symptoms present in multiple sclerosis patients:
Dalfampridine is to treat any decrease in one' s speed of walking.
Fluoxetine or Prozac is for the treatment of depression as well as Zoloft or sertraline and amitriptyline or Elavil.
For muscle spasms, tizanidine, baclofen, diazepam and intrathecal baclofen could be taken.
For patients who have multiple sclerosis in relapsing forms, Interferon beta-1a or Avonex and Rebif are the treatment options in order to slow physical disability as well as decrease clinical exacerbations.
Essentially, interferon' s function through a receptor which activates the pathway of the Jak/Stat of transduction signal molecules which then leads to the activation of the genes responsive to interferon.
For tonic painful spasms, Tegretol or carbamazepine is advised as well as Baclofen, gabapentin or Neurontin, and phenytoin.
Meanwhile, for fatigue, patients are advised to take fluoxetine, amanatadine and Ritalin or methylphenidate.
To address urinary dysfunction, pro-Banthine is advised or Propantheline bromide, oxybutynin or Ditropan, tolterodine tartrate and Tofranil or imipramine.
Tremors are resolved by Klonopin or Clonazepam, propranolol or Inderal, primidone or Mysoline, weighted bracelets or gabapentin.
For erectile dysfunction, medications include Viagra or Sildenafil, Levitra or vardenafil, Cialis or tadalafil, Muse or alprostadil. Take note that intracoporeal papaverine is not approved yet by the FDA.
Taking Avonex, Rebif, Extavia or Betaseron may produce flu-like symptoms which could then be decreased by taking analgesics
Meanwhile, immunomodulators are agents which help decrease clinical attacks or the quantity of multiple sclerosis lesions as these have a great impact on the progression of the disability.
However, precautions for taking this medication include pneumonia infections, severe depression, hypersensitivity reactions, UTI and other mild infections in the lower respiratory tract or vagina. Other effects include joint pain, mestrual disorder, urticaria, rigors as well as clinically significant hepatoxicity.
Meanwhile corticosteroids are agents which decrease acute inflammation and make recovery quicker from acute multiple sclerosis exacerbations. These could also be utilized for rescue therapy especially as monthly boosters for those who do not respond well to immunomodulators. Take note that methylprednisolone possess better anti-inflammatory potency compared to prednisolone and also have decreased tendency to induce sodium and water retention.
Also, methylprednisolone or Solu-Medrol as well as Depo-Medrol are used for the treatment of autoimmune and inflammatory reactions.